Eur J Intern Med 21(4):293-6 Nov 2010 3) Matalka MS, Ravnan MC, Deedwania PC. High- Intensity (lowers LDL-C ≥ 50%) 63. Why it matters: 2014 NICE guidance on primary and secondary lipid modification recommends the use of a high-intensity statin (i.e. CMAJ 181 (1-2). Background. a 31% to 40% reduction is medium intensity. Reduction. 40 mg ($196) 62. Whether use of high‐intensity statins is more important than achieving low‐density lipoprotein cholesterol (LDL ‐C) target remains controversial in patients with coronary artery disease.We sought to investigate the association between statin intensity and long‐term clinical outcomes in patients achieving treatment target for LDL ‐C after percutaneous coronary intervention. E11-E18 7 July, 2009 2) Degreef LE and Opdam FL. For the purpose of this guideline, statins are grouped into 3 different intensity categories according to the percentage reduction in low density lipoprotein cholesterol: a 20% to 30% reduction is low intensity. Lovastatin. one that reduces LDL cholesterol by 40% or more) with a low acquisition cost. 56. Pitavastatin. Moderate- or low-intensity statin was effective enough in reaching National Cholesterol Education Program Adult Treatment Panel III LDL-C target goals in Koreans. 61. Although these findings were retrospective in nature and confirmatory studies are required, this report suggests that statins can safely be used in patients with extremely low low-density lipoprotein levels and may lead to improved survival. a reduction of more than 40% is high intensity. Remarkably, statin use was associated with improved outcomes at all levels of low-density lipoprotein, even in subjects with values below 40 mg/dL. 1) Markus Mohaupt and others. 52. HMG-CoA Reductase Inhibitor. Atorvastatin. 60. Low and medium intensity statins by all CCGs. 58. Fluvastatin. 20 mg ($196) 54. 10 mg ($196) 50. The tolerability and efficacy of low-dose simvastatin in statin-intolerant patients. Rosuvastatin. Low-intensity statin showed around 30% LDL-C reduction from the baseline level in Koreans, which is comparable to moderate-intensity stat … Simvastatin. Association between statin-associated myopathy and skeletal muscle damage. Statin Intensity %LDL-C. Statin Moderate Daily Adult Dose Providing Similar Average LDL-Lowering(based on reference 1 unless otherwise denoted) Low -intensity (expected LDL reduction <30%) -intensity (expected LDL reduction 30 to <50%) High intensity (expected LDL reduction 50% or higher) Pitavastatin (Livalo)(U.S.) 1 mg 2 to 4 mg Use an initial dose of 1 mg in patients 80mg ($9 gen, $236 br) 59. Pravastatin.
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